Proteolytic interstitial cell migration: a five-step process

Cell Migration: A Physically Integrated Molecular Process

We further attempt to suggest generalizations across Perspective a wide spectrum of migratory cell types, including amoeCell migration plays a central role in a wide variety of bae, leukocytes, fibroblasts, and neurons, looking for biological phenomena. In embryogenesis, cellular mibroad similarities among physical mechanisms. Obsergrations are a recurring themein important morphogenic vations ...

Five-step process provides framework for managing supplies.

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

We present a cascade of proteolytic events catalyzed by the proteases secreted by cultured keratinocytes and fibroblasts that results in the activation of interstitial procollagenase. Cultured human skin fibroblasts constitutively secrete interstitial collagenase and stromelysin as proenzymes. In contrast, interstitial collagenase found in serum-free skin organ culture conditioned medium is act...

Proteolytic and non-proteolytic migration of tumour cells and leucocytes.

The migration of different cell types, such as leucocytes and tumour cells, involves cellular strategies to overcome the physical resistance of three-dimensional tissue networks, including proteolytic degradation of extracellular matrix (ECM) components. High-resolution live-cell imaging techniques have recently provided structural and biochemical insight into the differential use of matrix-deg...

A case study of a five-step design thinking process in educational museum game design

We present a case study in the design of an educational video game about collecting, curating, and museum operations. A five-step cyclic design thinking framework was used by the studio during the design and development of the game, and the team was simultaneously the subject of a rigorous and detailed ethnographic study. Three stages of the game’s design evolution are presented through the len...